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Topic Title: "I HOPE that Hydroxychloroquine Wins" Topic Summary: Created On: 04/05/2020 07:28 AM |
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04/06/2020 02:08 PM
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No one dies from trying this. At worst, it doesn't help. Doesn't make it worse or anything. In particular, the cardiac aspects are serious. Anyone with an arrythmia like atrial fibrillation (AF) or atrial flutter (AFl) is more susceptible to bad stuff. Chloroquine, and also Z-pack (which some trials are using together) both have the tendency to cause "QT prolongation" (lengthening the duration of the Q-R-S-T) portion of the cardiac cycle. Excessive lengthening can lead to a rhythm called "Torsade de pointes" that can be fatal unless treated immediately. https://en.wikipedia.org/wiki/Torsades_de_pointes Many patients with AF or AFl are already on rhythm control drugs that can also prolong QT unless they are always dosed and administered correctly. The combination of all 3 (chloroquine, Z-pack, and an antiarrythmic) is classified as an extremely MAJOR interaction risk. In general, most docs now know this, and the study-related articles I've seen also reflect this, but there are cases where it could slip through the cracks. Tpap is correct about the length of clinical trials. Nothing is likely to be "definitively good" any time soon. When you're breaking new ground, the trend is for anecdotal evidence and "related evidence" to provide ideas for clinical trials, and that's pretty much where we are now. As of last night, the WHO website listed 306 trials getting underway to address COVID-19. Some sound pretty whack, but at least they're running in parallel and may yield useful results faster than a serial approach. I would go deep with a Hail Mary if I were that deep in the woods. Edited: 04/06/2020 at 02:16 PM by RegularJoe |
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04/06/2020 02:13 PM
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No one dies from trying this. At worst, it doesn't help. Doesn't make it worse or anything. In particular, the cardiac aspects are serious. Anyone with an arrythmia like atrial fibrillation (AF) or atrial flutter (AFl) is more susceptible to bad stuff. Chloroquine, and also Z-pack (which some trials are using together) both have the tendency to cause "QT prolongation" (lengthening the duration of the Q-R-S-T) portion of the cardiac cycle. Excessive lengthening can lead to a rhythm called "Torsade de pointes" that can be fatal unless treated immediately. https://en.wikipedia.org/wiki/Torsades_de_pointes Many patients with AF or AFl are already on rhythm control drugs that can also prolong QT unless they are always dosed and administered correctly. The combination of all 3 (chloroquine, Z-pack, and an antiarrythmic) is classified as an extremely MAJOR interaction risk. In general, most docs now know this, and the study-related articles I've seen also reflect this, but there are cases where it could slip through the cracks. In short, even if it does work, it's not going to work for everyone. On the true medical side, there are already some positive results coming out of medical labs. Let's hope one is the real deal. ------------------------- I was right. |
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04/06/2020 02:23 PM
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In short, even if it does work, it's not going to work for everyone. That's true of a lot of therapies. In this one, researchers think they are seeing different patterns of response related to obesity, age, and possibly even blood type. Herceptin, a miracle drug in the breast cancer world, was almost abandoned because of unpredictable results. It wasn't until researchers discovered the subtle differences between receptor positive/negative aspects of different breast cancer cells they they identified the right recipients for it. When targeted to the right patients (with the right type of tumor), it works very well. There might be a similar scenario with the coronavirus. I've heard of 8 different (but still very similar) strains of the virus. Researchers would do well to identify it to that level when possible. Indeed! |
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04/06/2020 02:32 PM
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------------------------- "I remember South Africa in the late 70's, sleeping on the beach at J-bay, smoking ganja with the blacks. On weekends we'd go to the pub in East London to drink beer and fight with the Afrikaners. They liked to fight, I liked to fight. It was a good time" |
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04/06/2020 06:55 PM
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No one dies from trying this. At worst, it doesn't help. Doesn't make it worse or anything. In particular, the cardiac aspects are serious. Anyone with an arrythmia like atrial fibrillation (AF) or atrial flutter (AFl) is more susceptible to bad stuff. Chloroquine, and also Z-pack (which some trials are using together) both have the tendency to cause "QT prolongation" (lengthening the duration of the Q-R-S-T) portion of the cardiac cycle. Excessive lengthening can lead to a rhythm called "Torsade de pointes" that can be fatal unless treated immediately. https://en.wikipedia.org/wiki/Torsades_de_pointes Many patients with AF or AFl are already on rhythm control drugs that can also prolong QT unless they are always dosed and administered correctly. The combination of all 3 (chloroquine, Z-pack, and an antiarrythmic) is classified as an extremely MAJOR interaction risk. In general, most docs now know this, and the study-related articles I've seen also reflect this, but there are cases where it could slip through the cracks. In short, even if it does work, it's not going to work for everyone. On the true medical side, there are already some positive results coming out of medical labs. Let's hope one is the real deal. if you were sick; I suppose you wouldnt try it because trump is trying to bend the curve, help the world and dont take it when you get sick |
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04/07/2020 06:12 AM
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if you were sick; I suppose you wouldnt try it because trump is trying to bend the curve, help the world and dont take it when you get sick
Sick burn bro! Did you hire a screen writer for that one? ------------------------- I was right. |
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04/07/2020 06:55 AM
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For normal people, let me point out something that will show you what this is about. Note that the exact same people who are arguing against chloroquine are the ones who were vociferously arguing for the use of pot. Pot, of course, hasn't been tested for anything. So why are they so against this drug on the basis that it hasn't been tested? Because they don't want a drug to solve the problem. They want to maximize the death toll so as to get rid of Trump. That is how sick these people are. Don't vote for these crazy sickos.
------------------------- I :heart; Q |
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04/07/2020 07:00 AM
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For normal people, let me point out something that will show you what this is about. Note that the exact same people who are arguing against chloroquine are the ones who were vociferously arguing for the use of pot. Pot, of course, hasn't been tested for anything. So why are they so against this drug on the basis that it hasn't been tested? Because they don't want a drug to solve the problem. They want to maximize the death toll so as to get rid of Trump. That is how sick these people are. Don't vote for these crazy sickos. Tpap, please show where I am an advocate for pot. Please post a link. I'd love to see it. Tpap is so caught up in his lies and fabrication, nothing new here. Typical clown work... |
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04/07/2020 07:03 AM
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For normal people, let me point out something that will show you what this is about. Note that the exact same people who are arguing against chlorine are the ones who were vociferously arguing for the use of pot. Pot, of course, hasn't been tested for anything. So why are they so against this drug on the basis that it hasn't been tested? Because they don't want a drug to solve the problem. They want to maximize the death toll so as to get rid of Trump. That is how sick these people are. Don't vote for these crazy sickos. Tpap, please show where I am an advocate for pot. Please post a link. I'd love to see it. Tpap is so caught up in his lies and fabrication, nothing new here. Typical clown work... Not only that, but nobody is saying that we shouldn't try Chloroquine, we should, but we shouldn't be focused on it, considering it isn't a cure. ------------------------- I was right. |
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04/07/2020 07:04 AM
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it's the lawyer in him. Paid liar once, now it's just his natural state
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04/07/2020 07:06 AM
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it's the lawyer in him. Paid liar once, now it's just his natural state LOL he is not a lawyer |
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04/07/2020 07:21 AM
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Winning post there, folks.
------------------------- I :heart; Q |
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04/07/2020 11:10 AM
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------------------------- "I remember South Africa in the late 70's, sleeping on the beach at J-bay, smoking ganja with the blacks. On weekends we'd go to the pub in East London to drink beer and fight with the Afrikaners. They liked to fight, I liked to fight. It was a good time" |
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04/07/2020 11:47 AM
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it's the lawyer in him. Paid liar once, now it's just his natural state LOL he is not a lawyer He might be referring to tpap's boyfriend ------------------------- GOP: Gaslight Obstruct Project |
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04/08/2020 06:34 AM
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Just wanted to get in one more shot at the progs before this thread drops off of the front page. Two lessons here. First, progs are stupid. Second, they are more than willing to see their fellow Americans die to get at Trump. Very despicable people.
------------------------- I :heart; Q |
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04/08/2020 06:44 AM
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------------------------- ... |
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04/08/2020 06:47 AM
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Still waiting for the pot advocacy links.
------------------------- ... |
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04/08/2020 06:49 AM
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Of course, we wouldn't have those studies running now if some whacko hadn't first thought to step outside the box and give it a try.
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04/08/2020 06:50 AM
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Still waiting for the pot advocacy links. Funny thing is, for a surfing sight, you'd think you would see a lot of it. I don't think I've seen one pro pot post. Tpap just winging it as usual. |
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04/08/2020 06:56 AM
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Haha. Trying to change the subject now. They were advocating against a life saving treatment solely because Trump was pushing it. What scum.
PS. You find your own pot links, you lazy bastards. That's not my job.
------------------------- I :heart; Q |
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National Enquirer (FORMERLY NSR)
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"I HOPE that Hydroxychloroquine Wins"
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